Nanomedicine – Nanoparticle Characterisation

Accurate nanoparticle characterisation for nanomedicine development is expensive, slow and inaccurate. Oxford HighQ has developed an instrument that allows real time, rapid and consistent measurement of drug load across a nanoparticle population (both surface coating or internal drug loading) for targeted drug delivery through measurement of refractive index, providing a resolution of a few percent for particles from about 50 nm to 500 nm in size.

Our nanoparticle analyser is capable of measuring:

  • Particle size
  • Drug loading distribution
  • Drug unloading profiles
  • Porosity
  • Core to shell ratio
  • Refractive index
  • Quantitative measurement of coating efficiency

All on a particle-by-particle basis, using a bench top analytical instrument that is fast, accurate, easy to use and affordable to the general research community.

We have successfully demonstrated accurate, real time measurements of:

Drug loading and offloading profile of an API from
mesoporous silica nanoparticles

Shell Thickness Distribution of Core Shell Nanoparticles

Our particle-by-particle measurement greatly exceeds conventional techniques such as UV-Vis, especially as all measurements are done with no user interaction whilst the particles are offloading.

Our technology has also shown high-resolution size measurements (down to 5 nm) and can provide single nanoparticle sizing data similar to that obtained with TEM, but much faster and within native solutions, at a fraction of the TEM cost or complexity and with far less user training requirement.

In addition to mesoporous silica and core-shell nanoparticles, we are now working on characterising other drug loaded nanoparticles such as liposomes, polymeric particles, metallic particles and viral vectors.

Laboratory demonstration instruments are currently available to perform proof-of-capability measurements on customer samples and our first production version of the nanoparticle analyser for nanomedicine applications is entering its final development stage and will be shipping in 2021.

If you would like to receive updates including copies of our application and technical notes or are interested in having samples measured, please complete our contact request form.

 

Drug Load Distribution Graph

Figure 1: Drug loading distribution. Measured
percentage of CPC loaded nanoparticles
(within the loaded population) as a function
of the drug loading content

Shell Thickness Distribution

Figure 2: Measured shell thickness distributions of core-shell nanoparticles using optical microcavity analysis

Nanoparticle Analyser

Oxford HighQ Nanoparticle Analyser
concept drawing. Launching 2021.