NAnoparticle DRUG LOAD & UNLOADING MEASUREMENT

We have successfully demonstrated our ability to accurately measure the drug loading and offloading profile of cetylpyridinium chloride (CPC) from mesoporous silica nanoparticles. Figure 1 demonstrates the mean drug offloading as a function of time using a rolling average window of 350 seconds. A steady decrease followed by a sharp release is observed with full drug unloading seen after 40 minutes. Whilst in figure 2 we can see the drug loading distribution for the CPC as the percentage of loaded nanoparticles (within the loaded population) as a function of the drug loading content, which clearly shows that most of the nanoparticles have small loads of around 50 μg/mg.

If you would like to see the full results and experimental data, this is available in our application note.

Our particle-by-particle measurement greatly exceeds conventional techniques such as UV-Vis, especially as all measurements are done with no user interaction whilst the particles are offloading.

We have also successfully demonstrated real time measurements of the shell thickness distribution of core-shell nanoparticles on a particle-by-particle basis

Laboratory demonstration instruments are currently available to perform proof-of-capability measurements on customer samples and our first production version of the nanoparticle analyser for nanomedicine applications is entering its final development stage and will be shipping in 2021.

If you would like to receive updates including copies of our application and technical notes or are interested in having samples measured, please complete our contact request form.

 

Drug unloading from mesoporous silica nanoparticles

Figure 1: Drug release profile showing decrease in drug loading (in μg/mg) over time, with a steady decrease from time 0 until 40 minutes. Shadowed regions represent 15th to 85th percentile confidence intervals.

Nanoparticle Analyser

Figure 2: Drug loading distribution. Measured
percentage of CPC loaded nanoparticles
(within the loaded population) as a function
of the drug loading content