Shell Thickness Distribution of Core Shell Particles

We have successfully demonstrated real time measurements of the shell thickness distribution of core-shell nanoparticles on a particle-by-particle basis, proving our ability to characterise highly engineered nanoparticles with complex structures, and showing the capability of this technique to characterise particles relevant to nanomedicine such as protein-coated nanoparticles, viruses and liposomes.

Figure 1 shows results obtained using our optical microcavity analysis (OMCA) technology compared to those found using the conventional techniques of Dynamic Light Scattering (DLS), Thermogravimetric Analysis (TGA) and Differential Centrifugal Sedimentation (DCS), using Scanning Electron Microscopy SEM measurements as the reference for the bottom axis. Our limit of detection for the nanoparticles is estimated at 2 nm shell thickness.

Figure 2 shows OMCA inferred shell thicknesses for each of the core-shell samples measured, where further insight can be gained into the distributions of the particle compositions. 

Our measurements demonstrate our ability to measure the composition and shell thickness of PTFE/PS core-shell particles and these measurements have been independently verified using other measurement techniques.

If you would like to see the full results and experimental data, this is available in our application note

We have also demonstrated our ability to accurately measure the drug loading and offloading profile of an API from mesoporous silica nanoparticles on a particle-by-particle basis.

Laboratory demonstration instruments are currently available to perform proof-of-capability measurements on customer samples and our first production version of the nanoparticle analyser for nanomedicine applications is entering its final development stage and will be shipping in 2021.

If you would like to receive updates including copies of our application and technical notes or are interested in having samples measured, please complete our contact request form.

 

Core Shell Thickness Measurement

Figure 1: Oxford HighQ’s Optical Microcavity Analysis (OMCA), TGA, DLS and DCS inferred shell thicknesses compared to an SEM reference measurement

Shell Thickness Distribution

Figure 2: Measured shell thickness distributions of core-shell nanoparticles using optical microcavity analysis